COCA

Effect of Intravenous or Intraosseous Calcium vs Saline on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial

MF Vallentin, @LarsWAndersen1. JAMA 2021; Published online November 30, 2021. doi:10.1001/jama.2021.20929

Clinical Question
-  In patients with out-of-hospital cardiac arrest, does the administration of calcium compared with placebo, improve sustained return of spontaneous circulation?

N = 397, Denmark

Authors’ Conclusions
-  In patients with out-of-hospital cardiac arrest, treatment with calcium, compared with saline, did not significantly improve sustained return of spontaneous circulation

The Bottom Line
-  In patients with out-of-hospital cardiac arrest, treatment with calcium compared with saline, at a median of 17 minutes post cardiac arrest, did not significantly improve sustained return of spontaneous circulation.
-  The point estimates suggest clinically significant harm from the use of calcium in this population