SNOCAT

Effect of Out-of-Hospital Sodium Nitrite on Survival to Hospital Admission After Cardiac Arrest: A Randomized Clinical Trial

Kim @uwcardiology. JAMA. 2021 January 12;325(2):138-145. doi: 10.1001/jama.2020.24326.

Clinical Question
-  In patients with out-of-hospital cardiac arrest, does sodium nitrite, compared with placebo, improve survival to hospital admission?

N = 1502, Washington State USA

Authors’ Conclusions
-  Among patients with out-of-hospital cardiac arrest, administration of sodium nitrite, compared with placebo, did not significantly improve survival to hospital admission. These findings do not support the use of sodium nitrite during resuscitation from out-of-hospital cardiac arrest.

The Bottom Line
-  This appears to be a well-designed study with convincing data to support the authors’ conclusion that sodium nitrate is not useful during resuscitation from out-of-hospital cardiac arrest