TTM2

Hypothermia versus Normothermia after Out-of-Hospital Cardiac Arrest
Dankiewicz J for the TTM2 Trial Investigators. NEJM June 17, 2021 DOI:10.1056/NEJMoa2100591

Clinical Question

• In patients who are unconscious following out-of-hospital cardiac arrest, does targeted hypothermia compared with targeted normothermia, impact all-cause mortality?

N = 1900, 14 countries with 61 institutions

Authors’ Conclusions
-  In patients suffering out-of-hospital cardiac arrest, induced hypothermia did not lead to lower mortality
-  Functional outcome and health related quality of life did not improve from hypothermia

The Bottom Line
-  I will aim for normothermia in my patients following out of hospital cardiac arrest. I will implement targeted temperature management if temperature exceeds 37.7°C
-  Future exploration may include a trial of normothermia vs no targeted temperature management